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| 疏肝健脾法联合地塞米松治疗肝郁脾虚型肿瘤相关性乏力临床疗效及对外周血T细胞、NK细胞、IL-6的影响 |
| Soothing liver and strengthening spleen method combined with dexamethasone in the treatment of cancer-related fatigue of liver stagnation and spleen deficiency: Clinical Efficacy and Peripheral Blood T Cells, NK Cells and IL-6 Effects |
| 投稿时间：2023-08-31 修订日期：2023-08-31 |
| DOI： |
| 中文关键词: 肿瘤相关性乏力 肝郁脾虚型 疏肝健脾法 地塞米松 临床观察。 |
| 英文关键词: Cancer-related fatigue Liver stagnation and spleen deficiency Soothing liver and strengthening spleen method Dexamethasone Clinical observation. |
| 基金项目:浙江省中医药科技计划项目(2021ZA121) |
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| 中文摘要: |
| 目的：观察疏肝健脾法联合地塞米松治疗肝郁脾虚型肿瘤相关性乏力的临床疗效及对外周血T细胞、NK细胞、IL-6的影响。方法：选取63例肿瘤相关性乏力患者,按治疗方式不同分为对照组31例和治疗组32例,对照组予地塞米松10mg静滴治疗1次,治疗组在对照组基础上口服疏肝健脾中药颗粒治疗2周。2周后评估临床疗效,比较2组治疗前后MFI-20疲劳积分、中医证候积分、抑郁程度积分、T细胞和NK细胞活性、IL-6受体水平的变化。结果：治疗组临床疗效总有效率为71.88%,对照组为41.39%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分、抑郁程度积分下降,T细胞和NK细胞活性上升,IL-6受体水平下降(P<0.05)。治疗组MFI-20疲劳积分、中医证候积分、抑郁程度积分、IL-6受体水平低于对照组组,T细胞和NK细胞活性高于对照组(P<0.05)。结论：疏肝健脾法联合地塞米松治疗肝郁脾虚型肿瘤相关性乏力可缓解患者临床症状,调控免疫功能,提高临床疗效。 |
| 英文摘要: |
| Objective: To observe the clinical effect and peripheral blood T cells, NK cells and IL-6 effects of Soothing liver and strengthening spleen method combined with dexamethasone in the treatment of cancer-related fatigue of liver stagnation and spleen deficiency. Methods: Sixty-three patients with cancer-related fatigue were divided into the control group (31 cases) and the treatment group (32 cases) according to different treatment methods, with 31 and 32 cases in each group respectively. The control group was treated with dexamethasone 10mg once by intravenous drip, and the treatment group was additionally treated with Soothing liver and strengthening spleen Chinese medicine granules for 2 weeks on the basis of the control group. After 2 weeks of treatment, the clinical efficacy was evaluated, and the changes of MFI-20 fatigue score, TCM syndrome score, depression score, T cell and NK cell activity and IL-6 receptor level were compared between the two groups before and after treatment. Results: The total clinical effective rate was 71.88% in the treatment group and 41.39% in the control group, the difference was statistically significant (P<0.05). After treatment, the TCM syndrome scores and depression scores were decreased, the activities of T cells and NK cells were increased, and the level of IL-6 receptor was decreased in the two groups when compared with those before treatment (P<0.05). TThe MFI-20 fatigue score, TCM syndrome score, depression score and IL-6 receptor level in the treatment group were lower than those in the control group, and the activities of T cells and NK cells were higher than those in the control group after treatment (P<0.05). Conclusion: Soothing liver and strengthening spleen method combined with dexamethasone in the treatment of cancer-related fatigue of liver stagnation and spleen deficiency can relieve the clinical symptoms, regulate the immune function, and improve the curative effect. |
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