文章摘要
张梅教授自拟温阳通络方治疗紫杉醇(白蛋白结合型)所致周围神经毒性的经验
Professor Zhang Mei"s experience in treating peripheral nerve toxicity caused by paclitaxel albumin-binding type with Wenyang Tongluo formulaZhu Ming wu1,Zhang Mei2
投稿时间:2023-08-18  修订日期:2023-08-23
DOI:
中文关键词: 紫杉醇(白蛋白结合型)  周围神经毒性  温阳通络方  经验
英文关键词: Paclitaxel (albumin-bound)  Peripheral nerve toxicity  Wenyang Tongluo formula  EXP
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中文摘要:
      注射用紫杉醇(白蛋白结合型)现在广泛应用于多种实体瘤的治疗;而足剂量紫杉醇(白蛋白结合型)所致周围神经毒性目前尚无治疗的标准方案,可能导致剂量减少或无法继续治疗。张梅教授从中医辨证分析紫杉醇(白蛋白结合型)属寒毒之品,其所致周围神经毒性的中医病因病机是寒毒侵袭机体,致血虚寒凝,瘀阻脉络;故以温阳通络,益气养血、补益肝肾为治则,并运用上述理论指导临床实践。自拟温阳通络方(独活寄生汤为基础去甘草、人参、肉桂加黄芪、伸筋草、络石藤、鸡内金、附片、党参、桂枝而成)治疗紫杉醇(白蛋白结合型)所致周围神经毒性,减轻患者化疗后寒凉麻木刺痛不适,提升生活质量;为抗肿瘤治疗保驾护航。
英文摘要:
      Paclitaxel for injection (albumin-bound) is now widely used in the treatment of a variety of solid tumors; However, there is no standard treatment for peripheral nerve toxicity caused by sufficient doses of paclitaxel (albumin-binding type), which may lead to dose reduction or no further treatment. Professor Zhang Mei analyzed from TCM syndrome differentiation that paclitaxel (albumin-binding type) is a cold toxin. The etiology and pathogenesis of peripheral nerve toxicity caused by paclitaxel is cold toxin invading the body, causing blood deficiency and cold coagulation, and stasis blocking the vein; So to warm Yang Tongluo, tonifying qi and blood, tonifying liver and kidney as the treatment principle, and apply the above theory to guide clinical practice. Wenyang Tongluo prescription (Duhuashi Decoction as the basis to remove licorice, ginseng, cinnamon plus astragalus, Shenjincao, Luoshiteng, Radix japonicae, attached tablets, codonopsis, cassia twig) treatment of paclitaxel (albumin-binding type) induced peripheral nerve toxicity, alleviate cold, numbness, tingling discomfort, improve quality of life; Escort for anti-tumor therapy.
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