| Abstract: Objective To investigate the therapeutic effect of Yinzhihuang granules combined with Blaird''s yeast powder on pathological jaundice in newborns. Methods From June 2019 to January 2020, 160 neonates with pathological jaundice were treated in the pediatric department of our hospital as the research subjects. They were divided into control group and observation group according to the time of consultation, 80 cases each. The children in both groups were given basic treatments such as blue light irradiation. The children in the control group were treated with Blairrella powder on the basis of conventional treatment. The children in the observation group were treated with Yin Zhihuang granules on the basis of the control group. Statistical analysis of serum total bilirubin, jaundice regression time, length of hospital stay, and total effective rate before and after treatment in two groups of children. Changes in CD3+, CD4+, CD8+, and CD4+/ CD8+levels before and after treatment were recorded in both groups. Adverse reactions occurred during the period. Results After treatment, the average serum total bilirubin of the two groups was significantly reduced, but the serum total bilirubin level of the observation group was significantly lower than that of the control group. The jaundice remission time and hospital stay of the observation group were significantly shorter than Compared with the control group; the total effective rate of children in the observation group was significantly higher than that in the control group (P<0.05); there was no significant difference in CD8+levels between the two groups of children after treatment (P ＞0.05). CD3+, CD4+, and CD4+/CD8+ levels were significantly improved compared with before treatment, and the improvement of the children in the observation group was due to the control group (P <0.05); the number of fever, rash and diarrhea in the observation group was lower than that in the control group, and the incidence of total adverse reactions was significantly lower. In the control group (P <0.05). Conclusion Yinzhihuang granules combined with Blaird''s yeast powder can improve the clinical efficacy and reduce the incidence of adverse reactions by improving the levels of CD3+, CD4+, and CD4+/CD8+.