文章摘要
自拟健脾消肿汤合糖皮质激素治疗风水相搏型肾病综合征患儿临床观察
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投稿时间:2019-12-15  修订日期:2019-12-15
DOI:
中文关键词: 自拟健脾消肿汤  糖皮质激素  风水相搏型  肾病综合征  患儿  临床观察
英文关键词: self-designed jianpi yishen detumescence soup  Low dose glucocorticoids  Geomantic fighting pattern  Nephrotic syndrome  Children  Clinical observation
基金项目:
作者单位E-mail
王爽爽 浙江中医药大学附属第三医院 浙江 杭州 310000 tongliqin0101@126.com 
胡丹丹 浙江中医药大学附属第三医院 浙江 杭州 310000  
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中文摘要:
      目的:观察自拟健脾消肿汤合糖皮质激素治疗风水相搏型肾病综合征患儿临床观察。方法:选择2016年1月至2018年8月在我院门诊及住院的风水相搏型肾病综合症患儿68例,随机分为对照组和治疗组,各34例。对照组给予口服泼尼松1.5~2.0 mg/ (kg.d) ,最大剂量40 mg/d,分次口服,连续治疗1月。治疗组在对照组基础上给予口服自拟健脾消肿汤剂,每日1剂,水煎150-200ml,早晚分温服,连续治疗1月。观察2组患儿临床疗效及治疗前后24 h尿蛋白定量、尿素氮 (BUN) 、血肌酐 (SCr) 、尿微量白蛋白变化情况。结果 治疗组总有效为97.06%,对照组总有效为82.35%,二者差异有统计学意义(P<0.05)。治疗后,2组24 h尿蛋白定量、BUN、SCr、尿微量白蛋白水平均明显降低 (P<0.05) ,且治疗组下降幅度显著于对照组 (P<0.05) 。 结论:自拟健脾消肿汤合糖皮质激素能提高风水相搏型肾病综合征患儿临床疗效,减轻尿蛋白,延缓肾损害,值得临床推广应用。
英文摘要:
      Objective:To observe the clinical observation of the children with fengshui phasomatic nephropathy syndrome treated by self-designed jianpi yishen detumescence decoction combined with small dose of glucocorticoid. Methods: from January 2016 to August 2018, 68 children with geomantic phasomatic nephrotic syndrome were selected in the outpatient and inpatient department of our hospital, and were randomly divided into control group and treatment group, with 34 cases each. The control group was given an oral prednisone between 1.5 and 2.0 mg/ (kg.d), with a maximum dose of 40 mg/d, divided into several times, and the treatment was continued for 1 month. On the basis of the control group, the patients in the treatment group were given an oral and self-designed decoction for strengthening spleen and nourishing kidney and reducing swelling, 1 dose per day, 150-200ml water decoction, and taken at different temperatures in the morning and evening, for consecutive treatment for 1 month. To observe the clinical curative effect of children in the 2 groups and the changes of urinary protein quantification, urea nitrogen (BUN), blood creatinine (SCr) and urinary microalbumin at 24 h before and after treatment. Results the total effective rate was 97.06% in the treatment group and 82.35% in the control group, and the difference was statistically significant (P < 0.05). After treatment, 24 h urinary protein quantification, BUN, SCr, and urinary microalbumin were significantly decreased in both groups (P<0.05), and the decrease rate in the treatment group was significantly higher than that in the control group (P<0.05). Conclusion: self-designed spleen-kidney and kidney-nourishing decoction combined with small dose of glucocorticoid can improve the clinical efficacy of children with fengshui phase-boxed nephrotic syndrome, alleviate urinary protein and delay renal damage, and is worthy of clinical application.
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