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| 血清瘦素水平与非酒精性脂肪肝患者中医证型、舌象的相关性研究 |
| study on the correlation between serum leptin level and TCM syndrome types、tongue pictures in patients with nonalcoholic fatty liver disease |
| 投稿时间：2019-12-13 修订日期：2019-12-13 |
| DOI： |
| 中文关键词: 中医证型 舌象 非酒精性脂肪肝 瘦素 |
| 英文关键词: TCM syndrome types tongue picture nonalcoholic fatty liver disease leptin |
| 基金项目:2018年湖州市科技局科技计划项目（编号2018GY69）《芒硝外敷联合维生素E对非酒精性脂肪性肝病患者血清瘦素水平的影响》 |
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| 中文摘要: |
| 目的：探讨血清瘦素水平与非酒精性脂肪肝患者中医证型、舌象的关系。方法：纳入我院门诊和住院非酒精性脂肪肝患者152例,观察记录中医证候、舌象（舌体大小、舌质颜色、舌苔颜色、舌苔厚薄）、体重指数(BMI)、肝功能、血脂、血清瘦素、肝脏B超结果，将患者辩证分为湿浊内停型、痰热内蕴型、肝郁脾虚型、痰瘀互结型、脾肾两虚型，分析血清瘦素水平与中医证型和舌象的关系。结果：非酒精性脂肪肝患者中医证型以湿浊内停型最多，占31.57%。湿浊内停型和肝郁脾虚型体重指数明显高于痰热内蕴型、痰瘀互结型、脾肾两虚型(P <0.05)。痰瘀互结型 ALT 、AST、LEP显著高于湿浊内停型、湿热内蕴型、肝郁脾虚型、脾肾两虚型(P <0.05)。舌质暗组和舌苔厚组ALT、AST、LEP较舌淡红组、舌淡胖组、舌质红组、非舌苔厚组明显升高(P <0.05)。结论：血清瘦素水平与非酒精性脂肪肝患者中医证型、舌象有一定的关联，可作为其中医辨证分型的辅助指标并指导中医治疗。 |
| 英文摘要: |
| Objective: To investigate the correlations between Serum leptin level and TCM syndrome types and tongue pictures in patients with nonalcoholic fatty liver disease ( NAFLD) . Methods: TCM syndromes、tongue pictures、body mass index、liver function、blood lipids and serum leptin level of 152 NAFLD patients were recorded. The TCM syndromes of them could be typed into five TCM types, internal pause of dampness turbidity type,phlegm heat type,hepatic stagnation and spleen deficiency type,intermingling of phlegm and static blood type and deficiency of spleen and kidney type ,then the correlations between Serum leptin levels and TCM syndrome types and tongue pictures of patients with nonalcoholic fatty liver disease ( NAFLD) was analyzed. Results:Among them internal pause of dampness turbidity type was the commonest syndrome type,which accounted to 31.57%.The body mass index of patients with internal pause of dampness turbidity type and hepatic stagnation and spleen deficiency type was significently higher than them with other three types(P <0.05).The figures of ALT 、AST、LEP of patiens with intermingling of phlegm and static blood type were significently higher than that of patinets with other four types(P <0.05).The figures of ALT 、AST、LEP of patiens with dark tongue group and thick tongue coating group were much higher than that of patients with pale red tongue group and fat tongue group and red tongue group and non thick tongue coating group(P <0.05).Conclusion: Serum leptin level of patients with nonalcoholic fatty liver disease was correlated with TCM syndorome types and tongue pictures ,which can be used as an auxiary indicator for TCM syndrome differentiation. |
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