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| 葛根芩连汤加味治疗宫颈上皮内瘤变术后HPV持续感染的临床疗效 |
| The clinical efficacy of modified Ge Gen Lian Decoction in managing persistent HPV infection following surgical intervention for cervical intraepithelial neoplasia |
| 投稿时间：2025-04-18 修订日期：2025-04-18 |
| 中文关键词: 葛根芩连汤 宫颈上皮内瘤变 HPV持续感染 免疫功能 微炎症 |
| 英文关键词: |
| 基金项目:绍兴市中西医结合学会资助项目(2022ZXY08) |
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| 中文摘要: |
| 目的 探究葛根芩连汤加味治疗宫颈上皮内瘤变术后HPV持续感染的临床疗效。方法 选取2022年1月至2024年3月我院诊治的宫颈上皮内瘤变 CIN Ⅱ~Ⅲ术后HPV持续感染的患者,共127例,随机分成观察组(67例)和对照组(60例),其中对照组给予干扰素阴道泡腾片治疗,观察组在对照组的基础上应用葛根芩连汤加味,持续治疗6个月,观察葛根芩连汤加味对于宫颈上皮内瘤变术后HPV持续感染患者的干预效果。结果 观察组治疗后的中医症候量化积分均较本组治疗前和对照组治疗后明显降低；观察组的HPV转阴率(89.55%)和病理逆转率(90.90%)明显优于对照组(58.33%、55.55%)(均P＜0.05)；观察组治疗后CD3+、CD4+、CD4+/CD8+等水平均较本组治疗前和对照组治疗后明显升高(均P＜0.05)；观察组治疗后hs-CRP、SAA和IL-6等水平较本组治疗和观察组治疗后显著降低(均P＜0.05)。结论 葛根芩连汤加味能有效改善宫颈上皮内瘤变术后HPV持续感染患者的临床症状,降低体内微炎症状态,提高免疫功能境,促进阴道内HPV转阴,改善预后。 |
| 英文摘要: |
| [Abstract] Objective: To investigate the clinical efficacy of modified modified Ge Gen Qin Lian Decoction in managing persistent HPV infection following cervical intraepithelial neoplasia (CIN) II-III surgery. Methods: A total of 130 patients with persistent HPV infection after CIN II-III surgery, treated at our hospital between January 2022 and March 2024, were randomly assigned to an observation group (n=67) and a control group (n=63). The control group received interferon vaginal effervescent tablets, while the observation group was administered modified Kudzuvine Decoction in addition to the control treatment for six months. The therapeutic effects of modified Kudzuvine Decoction on patients with persistent HPV infection post-CIN II-III surgery were evaluated. Results: After treatment, the quantitative scores of TCM syndromes in the observation group were significantly lower than those before treatment within the same group and after treatment in the control group (all P < 0.05). The HPV negative conversion rate (89.55%) and pathological regression rate (90.90%) in the observation group were markedly higher than those in the control group (58.33% and 55.55%, respectively) (all P < 0.05). Additionally, the levels of CD3+, CD4+, and CD4+/CD8+ in the observation group after treatment were significantly higher compared to pre-treatment levels within the same group and post-treatment levels in the control group (all P < 0.05). Furthermore, the levels of hs-CRP, SAA, and IL-6 in the observation group after treatment were significantly reduced compared to pre-treatment levels within the same group and post-treatment levels in the control group (all P < 0.05). Conclusion: Modified modified Ge Gen Qin Lian Decoction effectively alleviates clinical symptoms in patients with persistent HPV infection following CIN II-III surgery, reduces systemic micro-inflammatory states, enhances immune function, promotes HPV clearance in the vagina, and improves overall prognosis. |
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