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| 参芪草子饮对老年糖尿病肾病患者氧化应激反应及外周血Smad1蛋白的影响 |
| Effects of ginseng astragalus and grass seed drink on oxidative stress and peripheral blood Smad1 protein in elderly patients with diabetic nephropathy |
| 投稿时间：2024-12-27 修订日期：2024-12-27 |
| 中文关键词: 参芪草子饮 糖尿病肾病 氧化应激 疗效 不良反应 |
| 英文关键词: Ginseng astragalus and grass seed drink Diabetic nephropathy Oxidative stress Efficacy Adverse effects |
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| 中文摘要: |
| 目的 观察参芪草子饮对老年糖尿病肾病患者氧化应激反应及外周血Smad同源物1(Smad1)蛋白的影响。方法 病例选时间为2022年6月～2024年3月,研究人群为在我院接受治疗的116例糖尿病肾病患者,采用简单随机法分为两组。对照组给予达格列净治疗,中药饮组在对照组基础上联合参芪草子饮治疗。比较两组肾功能、Smad1蛋白、NOD样受体蛋白3(NLRP3)、氧化应激反应、中医症候评分变化,记录两组总有效率及不良反应率。结果 两组治疗前肾功能、氧化应激反应比较,无差异(P>0.05)。治疗前后比较,两组超氧化物歧化酶(SOD)均升高,血肌酐(Scr)、丙二醛(MDA)、尿素氮(BUN)、24h尿蛋白定量、晚期蛋白氧化产物(AOPPs)、尿微量白蛋白(mALB)均降低(P<0.05)。中药饮组治疗后肾功能、MDA、AOPPs均低于对照组,SOD高于对照组(P<0.05)。两组治疗前Smad1蛋白、NLRP3比较,无差异(P>0.05)。治疗前后比较,两组Smad1蛋白、NLRP3均降低,中药饮组治疗后Smad1蛋白、NLRP3均低于对照组(P<0.05)。两组治疗前中医症候评分比较,无差异(P>0.05)。治疗前后比较,两组肢体浮肿、纳减便溏、神疲乏力、口渴多饮、腰膝酸痛、皮肤瘀斑及脘腹胀满评分均降低,中药饮组治疗后中医症候评分均低于对照组(P<0.05)。中药饮组总有效率为91.38%(53/58)高于对照组的77.59%(45/58),有差异(P<0.05)。两组不良反应比较,无差异(P>0.05)。结论 参芪草子饮可减轻老年糖尿病肾病患者氧化应激反应,降低外周血Smad1蛋白、NLRP3水平,提高疗效。 |
| 英文摘要: |
| Objective To observe the effects of ginseng astragalus and grass seed drink on oxidative stress and peripheral blood Smad homologue 1 (Smad1) protein in elderly patients with diabetic nephropathy.Methods The study period was from June 2022 to March 2024. A total of 116 diabetic nephropathy patients who received treatment in our hospital were enrolled and randomly divided into two groups using simple randomization. The control group received degarelix treatment. The Chinese herbal medicine group received degarelix combined with Shechuangzi Yin treatment based on the control group. The changes in renal function, Smad1 protein, NLRP3 protein, oxidative stress, and Chinese medicine symptom scores between the two groups were compared. The total effective rates and adverse reaction rates of the two groups were also recorded.Results Before treatment, there was no difference between the two groups in renal function and oxidative stress response (P>0.05). After treatment, superoxide dismutase (SOD) levels increased, while blood creatinine (Scr), malondialdehyde (MDA), blood urea nitrogen (BUN), 24-hour urinary protein quantification, advanced oxidation protein products (AOPPs), and urine microalbumin (mALB) decreased in both groups (P<0.05). After treatment, the Chinese herbal medicine group had better renal function, lower MDA and AOPPs levels than the control group, and higher SOD levels (P<0.05). Before treatment, there was no difference between the two groups in Smad1 protein and NLRP3 levels (P>0.05). After treatment, Smad1 protein and NLRP3 levels decreased in both groups, and the Chinese herbal medicine group had lower levels than the control group (P<0.05). Before treatment, there was no difference between the two groups in Chinese medicine symptom scores (P>0.05). After treatment, symptom scores for limb edema, anorexia, lassitude, thirst, low back and knee pain, skin bruising, and abdominal fullness and distention decreased in both groups, with lower scores in the Chinese herbal medicine group (P<0.05). The total effective rate of the Chinese herbal medicine group was 91.38% (53/58), higher than 77.59% (45/58) in the control group, with a significant difference (P<0.05). There was no difference in adverse reactions between the two groups (P>0.05).Conclusion Ginseng astragalus and grass seed drink can reduce oxidative stress in elderly diabetic nephropathy patients, reduce peripheral blood Smad1 protein and NLRP3 levels, and improve the therapeutic efficacy. |
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