针灸序贯疗法治疗女性乳腺增生病:随机对照研究

罗培; 沈林兴; 俞桔; 李娟娟

文章摘要

针灸序贯疗法治疗女性乳腺增生病:随机对照研究

Sequential Acupuncture and MoxibustionTherapy for Women with Mammary Gland Hyperplasia: a Randomized Controlled Study

投稿时间：2024-10-09 修订日期：2024-10-09

DOI：

中文关键词: 针灸序贯疗法乳腺增生病疼痛激素随机对照研究

英文关键词: Sequential Acupuncture and Moxibustion Therapy Mammary Gland Hyperplasia Pain Hormones Randomized Controlled Trial

基金项目:浙江省中医药科技研究项目(No.2021ZB298)

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中文摘要:

目的：观察针灸序贯疗法治疗女性乳腺增生病的疗效及安全性。方法：将93例乳腺增生病女性患者随机分成3组，对照组、治疗1组和治疗2组，各31例。对照组采用常规女性乳腺增生病保养方法，未予治疗干预，治疗1组在对照组的基础上，口服乳癖消片（辽宁好护士），5片，日3次，口服，经期停用。治疗2组：在对照组基础上，采用针灸序贯治疗，共3期，隔日治疗一次。观察治疗前、治疗疗程结束后、随访1月的乳房肿块、乳房疼痛、伴随症状，及激素水平（雌二醇E2、卵泡刺激素FSH、黄体生成素LH），并评估针灸序贯疗法的有效率及安全性。结果：治疗结束后及治疗结束后4周随访，组内比较：治疗1组及治疗2组患者FSH、E2均比治疗前明显下降（P<0.05），LH明显上升（P<0.05），乳房肿块、疼痛及伴随症状评分均比治疗前明显减少（P<0.05）；组间比较：治疗2组FSH明显低于对照组及治疗1组（P<0.05），三组之间E2、LH均无明显差异（P>0.05）。治疗1组及治疗2组乳房肿块、疼痛评分、伴随症状评分均明显小于对照组（P<0.05），且治疗2组乳房肿块、疼痛评分小于治疗1组（P<0.05）。治疗结束后激素水平、乳房肿块评分、疼痛评分及伴随症状评分与治疗结束后4周随访时，无明显差异（P>0.05）。对照组、治疗1组、治疗2组的总有效率分别为61.29%、77.42%、90.32%，治疗2组总有效率明显高于对照组及治疗1组（P＜0.05）。整个治疗疗程中，三组均未出现不良反应。结论：针灸序贯疗法可改善激素水平，改善乳腺增生病的乳房肿块、疼痛及伴随症状，疗法安全，并具有良好的近期与远期效应。

英文摘要:

Objective: To observe the efficacy and safety of sequential acupuncture and moxibustion therapy in the treatment of female mammary gland hyperplasia. Method: A total of 93 cases of female mammary gland hyperplasia were randomized into 3 groups: control group(n=31), treatment group 1 and treatment group 2(n=31). The patients in control group received routine maintenance of female mammary hyperplasia without treatment intervention. On the basis of the control group, treatment group 1 was given oral Rupixiao tablets (Liaoning Good Nurse), 5 tablets, 3 times a day, orally, and menstrual cessation. On the basis of the control group, sequential acupuncture and moxibustion therapy was used, a total of 3 course, once every other day. Breast mass, breast pain, associated symptoms, and hormone levels (E2, FSH, LH) were observed before treatment, after treatment, and 1 month follow-up, then the effectiveness and safety of sequential acupuncture and moxibustion therapy were evaluated. Result: After treatment and 4 weeks after treatment, intra-group comparison: FSH and E2 of patients in treatment group 1 and treatment group 2 were significantly decreased compared with those before treatment (P<0.05), LH was significantly increased (P<0.05), and scores of breast mass, pain and accompanying symptoms were significantly decreased compared with before treatment (P<0.05). Comparison between groups: FSH in treatment group 2 was significantly lower than that in control group and treatment group 1 (P<0.05), and E2 and LH were not significantly different among the three groups (P>0.05). The scores of breast mass, pain and accompanying symptoms in treatment group 1 and treatment group 2 were significantly lower than those in control group (P<0.05), and the scores of breast mass and pain in treatment group 2 were lower than those in treatment group 1 (P<0.05). There were no significant differences in hormone level, breast mass score, pain score and accompanying symptom score after treatment compared with 4 weeks after treatment (P>0.05). The total effective rate of control group, treatment group 1 and treatment group 2 was respectively 61.29%, 77.42% and 90.32%, and the total effective rate of treatment group 2 was significantly higher than that of control group and treatment group 1 (P < 0.05). During the whole course of treatment, there were no adverse reactions in the three groups. Conclusion: The sequential acupuncture and moxibustion therapy can improve hormone levels, relieve breast lumps, pain and associated symptoms of mammary gland hyperplasia. The therapy is safe with good short-term and long-term effects.

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