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| 类风湿性关节炎风险因素与中医体质的相关性研究 |
| A study on the correlation between rheumatoid arthritis risk factors and Chinese medicine physique |
| 投稿时间：2024-09-14 修订日期：2024-09-14 |
| DOI： |
| 中文关键词: 类风湿性关节炎 风险因素 中医体质 相关性 |
| 英文关键词: Rheumatoid arthritis Risk factors Chinese medicine constitution Correlation |
| 基金项目:浙江省台州市科技计划项目当归补血汤通过MAPK1、IL-6靶点及JAK/STAT 信号通路治疗类风湿性关节炎的机制研究及临床疗效评价,编号:2022S00123 |
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| 中文摘要: |
| 目的：本研究旨在探讨类风湿性关节炎（RA）的风险因素与中医体质之间的联系，并进一步研究通过中西医结合来预防和治疗RA的综合策略。方法：本研究选取台州骨伤医院住院的RA患者作为研究对象，研究期间为2023年全年，共纳入符合条件的有效病例100例。根据《中医体质分类与判定自测表》判别并分析患者的中医体质类型，同时收集患者的基本信息、合并症（如高血压、间质性肺疾病等）、年龄、性别以及实验室指标等数据作为风险因素。RA的诊断依据为2010年美国风湿病学会（ACR）/欧洲抗风湿病联盟（EULAR）关于RA的分类诊断标准及《国际中医临床实践指南 类风湿关节炎》。统计学分析采用SPSS25.0软件处理数据，使用χ²检验、t检验或秩和检验进行数据分析。结果：研究结果显示，在100例RA患者中，最常见的中医体质类型为湿热质（占30.00%），其次为阳虚质（18.00%）和血瘀质（14.00%）。此外，高血压是最常见的合并症（59.00%），其次是糖尿病（38.00%）。在实验室指标方面，虽然RF、抗CCP抗体和ESR在不同体质类型中的分布没有统计学意义，但是CRP的分布存在显著差异（P<0.05），特别是湿热质和血瘀质患者的CRP水平显著高于其他体质类型。结论：RA患者的中医体质主要以湿热质和阳虚质为主。为了控制RA的发展并改善患者的生活质量，需要通过调理和纠正患者的湿热和阳虚体质来进行干预。该研究对于RA的预防和治疗具有重要的临床意义。 |
| 英文摘要: |
| Objective：The aim of this study was to investigate the association between the risk factors of rheumatoid arthritis (RA) and Chinese medicine constitution, and to further investigate the comprehensive strategies for the prevention and treatment of RA through the integration of Chinese and Western medicine.
Methods：In this study, RA patients hospitalized in Taizhou Orthopaedic and Traumatology Hospital were selected as the study subjects, and the study period was the whole year of 2023, and a total of 100 eligible and valid cases were included. The patients'' TCM body types were identified and analyzed according to the TCM Body Type Classification and Determination Self-Assessment Scale, and basic information, comorbidities (e.g., hypertension, interstitial lung disease, etc.), age, gender, and laboratory indicators were collected as risk factors.The diagnosis of RA was based on the 2010 ACR/EULAR classification and diagnostic criteria and the International Clinical Practice Guidelines for Traditional Chinese Medicine (ICPGTM). The diagnosis of RA was based on the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) diagnostic criteria for RA and the International Clinical Practice Guidelines for Traditional Chinese Medicine (ICPGTM) for rheumatoid arthritis. Statistical analysis was performed using SPSS25.0 software, and data were analyzed using the χ² test, t-test or rank-sum test.
Results：The results of the study showed that among the 100 RA patients, the most common TCM constitution type was damp-heat constitution (30.00%), followed by yang-deficiency constitution (18.00%) and blood stasis constitution (14.00%). In addition, hypertension was the most common comorbidity (59.00%), followed by diabetes mellitus (38.00%). Regarding laboratory indicators, although the distributions of RF, anti-CCP antibody and ESR were not statistically significant in different body types, there was a significant difference in the distribution of CRP (P<0.05), especially in patients with Damp-Heat and Blood Stasis qualities, which had significantly higher CRP levels than the other body types.
Conclusion：The traditional Chinese medicine (TCM) constitution of RA patients is mainly characterized by damp-heat and yang-deficiency constitutions. In order to control the development of RA and improve the patients'' quality of life, intervention is needed by regulating and correcting the patients'' damp-heat and Yang-deficiency constitution. This study has important clinical significance for the prevention and treatment of RA. |
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