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| 冠心宁片减轻急性心肌梗死缺血再灌注损伤的临床研究 |
| Clinical study of Guanxinning tablet alleviating ischemia reperfusion injury |
| 投稿时间：2024-05-22 修订日期：2024-05-22 |
| DOI： |
| 中文关键词: 急性心肌梗死 冠心宁片 炎症因子 心血瘀阻型 心功能 |
| 英文关键词: acute myocardial infarction,Guanxinning tablet,inflammation factor,heart blood stasis syndrome,Heart function |
| 基金项目:浙江省医学会临床科研(2021ZYC-A60) |
| 摘要点击次数: 111 |
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| 中文摘要: |
| 目的 观察冠心宁片联合西药治疗心血瘀阻型急性心肌梗死患者缺血再灌注损伤的临床疗效并探讨其作用机制。方法 选取2022年06月至2023年12月在浙江省立同德医院确诊为急性心肌梗死并行再灌注治疗且辨证为心血瘀阻型的患者100例,通过随机数字表将其划分为对照组和观察组进行实验。对照组患者给予指南指导的西药治疗(GDMT,Guideline-directed medical therapy),观察组患者在GDMT的基础上联合冠心宁片治疗。比较两组缺血再灌注损伤发生率、临床疗效及中医症候疗效；比较两组间C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白介素-6(IL-6)、磷酸肌酸同工酶(CK-MB)、N端B型利尿钠肽前体(NT-proBNP)等生化指标变化,以及左心室射血分数(left ventricular ejection fraction,LVEF)、左室短轴缩短率(left ventricular fraction shorting,FS)等心功能指标变化。亚组分析,两组间缺血再灌注损伤病例治疗前后CK-MB、NT-proBNP、LVEF、IL-6变化。结果 两组间缺血再灌注损伤发生率差异有统计学意义(P>0.05)。治疗后中医症候疗效总有效率观察组高于对照组(P<0.05)。治疗后两组生化指标CRP、CK-MB、TNI、NT-proBNP水平均低于治疗前(均P<0.05),且观察组均低于对照组(均P<0.05)。治疗后两组患者左心室射血分数均高于治疗前,且观察组改变更明显。亚组分析:观察组中再灌注损伤病例治疗后CK-MB、NT-proBNP、IL-6明显低于对照组再灌注损伤病例,且LVEF高于对照组(均P<0.05)。结论 冠心宁片能够减轻缺血再灌注损伤,提高急性心肌梗死患者临床疗效,主要与其抑制心梗后炎症反应有关。 |
| 英文摘要: |
| Objective:To observe the clinical effect of Guanxinning tablet combined with Western medicine on ischemia-reperfusion injury in patients with acute myocardial infarction with blood stasis and explore its mechanism.Methods:From June 2022 to December 2023,A total of 100 patients diagnosed with acute myocardial infarction combined with reperfusion therapy in Tongde Hospital of Zhejiang Province were selected and divided into control group and observation group by random number table method.Control group was given GDMT (Guideline directed medical therapy), observation group was combined with Guanxinning tablet on the basis of GDMT.The incidence of ischemia-reperfusion injury, clinical efficacy and TCM symptoms were |
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