文章摘要
体外受精-胚胎移植助孕患者中医证型与妊娠结局的相关性研究
Study on the correlation between TCM syndromes and pregnancy outcomes in patients with in vitro fertilization-embryo transplantation
投稿时间:2024-04-17  修订日期:2024-04-17
DOI:
中文关键词: 体外受精与胚胎移植  中医  证型  妊娠结局
英文关键词: In virto fertilization and embryo transfer (IVF-ET)  Traditional Chinese medicine  Syndrome  pregnancy outcomes
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中文摘要:
      (洛阳市妇幼保健院):目的:研究IVF-ET助孕患者的中医证型与妊娠结局的相关性,以期为中医药辅助IVF-ET助孕提供辨证施治的临床依据。方法:将403例拟行IVF-ET助孕的不孕症患者作为研究对象,以问卷调查的方式采集临床资料,研究此类患者的证型分布情况以及证型分布的影响因素,并探讨证型分布对妊娠结局的影响。结果:①IVF-ET助孕患者中出现频率最高的证型为肝郁气滞证,其次为瘀阻胞宫证、痰湿阻滞证、脾肾阳虚证、肝肾阴虚证和胞宫湿热证,各证型的构成比有统计学差异(P<0.05);②不同年龄、BMI、内膜厚度之间的证型分布比较,有统计学差异(P<0.05),不同病程之间的证型分布比较无统计学差异(P>0.05);③不同中医证型之间的妊娠结局比较,胚胎着床率有统计学差异(P<0.05);临床妊娠率、早期流产率均无统计学差异(P>0.05)。结论:①肝郁气滞证是IVF-ET助孕患者最常见中医证型;②年龄、BMI和内膜厚度影响患者的中医证型分布;③中医证型分布影响新鲜周期的胚胎着床率。
英文摘要:
      Objective: To study the correlation between the TCM syndrome type and the pregnancy outcome of IVF-ET assisted pregnancy patients, in order to provide the clinical basis for syndrome differentiation treatment for traditional Chinese medicine-assisted IVF-ET pregnancy. Methods: 403 infertile patients with IVF-ET assisted pregnancy were taken as the research object, and clinical data were collected in the form of questionnaires to study the distribution of syndrome types and the influencing factors of syndrome distribution of such patients, and to explore the impact of syndrome distribution on pregnancy outcomes.Results:① The syndrome types with high frequency in IVF-ET patients were liver depression and qi stagnation syndrome, followed by blood stasis syndrome , phlegm dampness block syndrome , spleen and kidney yang deficiency syndrome , liver and kidney yin deficiency syndrome, uterus dampness heat syndrome, and the constituent ratio of each syndrome type was statistically significant (P<0.05);②There were significant differences in the distribution of TCM syndromes types among different ages, BMI and endometrial thickness (P<0.05),but there was no significant difference in the distribution of TCM syndromes types among different course of disease (P>0.05); ③There was significant difference in embryo implantation rate of fresh cycle between different TCM syndromes types (P <0.05), but there was no significant difference in clinical pregnancy rate and early abortion rate (P> 0.05).Conclusions: Liver depression and qi stagnation syndrome is the most common TCM syndrome type in IVF-ET patients; Age, BMI and endometrial thickness affect the distribution of TCM syndromes; The distribution of TCM syndromes affects the embryo implantation rate of fresh cycle.
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