文章摘要
益肾健骨汤联合骨化三醇治疗肾性骨病疗效观察
Observation on the curative effect of YiShenJianGu Decoction combined with ossifying triol in the treatment of renal bone disease
投稿时间:2019-12-23  修订日期:2019-12-23
DOI:
中文关键词: 肾性骨病  中医药  益肾健骨汤  骨代谢
英文关键词: 
基金项目:
作者单位E-mail
邵玲就 温州市中心医院 jfzyfhq@163.com 
傅海群 温州市中医院  
叶晓红 温州市中医院  
朱文宗 温州市中医院 m15990703311@163.com 
摘要点击次数: 41
全文下载次数: 0
中文摘要:
      摘要:目的:探讨益肾健骨汤联合骨化三醇治疗肾性骨病的临床疗效。方法:选取西医诊断为肾性骨病(肾功能衰竭期),中医辨证属肾精不足证的患者90例,随机分成治疗组、对照组A、对照组B各30例,治疗组在常规治疗基础上予益肾健骨汤及骨化三醇口服,对照组A予常规治疗加服用骨化三醇胶丸治疗,对照组B仅予常规治疗;检测治疗前及治疗后12周的血清肌酐、尿素氮、血钙、血磷、全段甲状旁腺激素,骨代谢指标:β-I型胶原C-末端肽、I型前胶原N端前肽、25羟维生素D、骨钙素;中医疗效评价,生存质量评价水平,比较3组在各项指标间的差异。结果:治疗组在血清肌酐、尿素氮、血磷、全段甲状旁腺激素,β-I型胶原C-末端肽(β-CTX)、I型前胶原N端前肽 (PINP)、骨钙素,较治疗前均有显著下降(P<0.01),且治疗组水平均优于对照组A、B,有显著差异(P<0.01);在血钙、25羟维生素D水平,中医疗效评价,生存质量评价方面较治疗前显著上升,差异具有统计学意义(P<0.01);治疗12周后,对照组A高钙血症发病率高于治疗组,差异具有统计学意义(P<0.01)。结论:益肾健骨汤及骨化三醇口服方案治疗肾性骨病能显著改善各项生化指标、骨代谢指标,提高善患者生存质量及中医临床疗效,且能降低高钙血症发生率,值得临床推广应用。
英文摘要:
      Summary Objective:To investigate the clinical effect of YiShenJianGu Decoction combined with calcitriol in the treatment of Renal Osteopathy.Methods:90 patients with Renal Osteopathy (hypertensive kidney lesion) and TCM syndrome differentiation of kidney essence deficiency were selected.They were randomly divided into treatment group,control group A and control group B,with 30 cases in each group. The treatment group in the routine treatment plus taking YiShenJianGu Decoction and calcitriol, control group A in the routine treatment plus taking calcitriol capsule treatment, control group B only with conventional treatment.Serum creatinine, urea nitrogen, Blood calcium,Blood phosphorus, parathyroid hormone, β-CTX, PINP, 25(OH)D3, osteocalcin were observed in 12th week. Efficacy evaluation of TCM and Quality of life evaluation level were compared among the three groups.Results: Serum creatinine, urea nitrogen, blood phosphorus, parathyroid hormone, β-CTX, PINP and osteocalcin in the treatment group were significantly decreased compared with those before treatment (P < 0.01). Blood calcium, 25(OH)D3 level, TCM efficacy evaluation and quality of life evaluation were significantly higher than those before treatment, with statistically significant differences (P < 0.01). After 12 weeks of treatment, the incidence of hypercalcemia in the control group A was higher than that in the treatment group, and the difference was statistically significant (P < 0.01).Conclusion: YiShenJianGu Decoction combined with calcitriol can significantly improve biochemical indicators and Bone metabolite ,rising the quality of life and the clinical efficacy of TCM, and reduce the incidence of hypercalcemia, which is worthy of clinical promotion and application.
View Fulltext   查看/发表评论  下载PDF阅读器
关闭