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| 温阳利水化瘀方联合腹腔热灌注化疗治疗恶性腹腔积液80患者的临床观察 |
| The Clinical Observation on Treatment of 80 Patients with Malignant Ascites by Warming Yang Lishui Huayu Recipe Combined with Intraperitoneal Hyperthermic Perfusion Chemotherapy |
| 投稿时间：2019-07-29 修订日期：2019-07-29 |
| DOI： |
| 中文关键词: 温阳利水化瘀方 阳虚型 恶性腹腔积液 腹腔热灌注化疗 |
| 英文关键词: Wenyang Lishui Huayu Decoction Yang deficiency type malignant ascites intraperitoneal hyperthermic perfusion chemotherapy |
| 基金项目: |
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| 中文摘要: |
| 目的：观察温阳利水化瘀方联合腹腔热灌注化疗治疗恶性腹腔积液的临床疗效及安全性。方法：将2016年07月—2018年07月期间我院肿瘤科门诊及住院部收治的80例阳虚型恶性腹腔积液患者根据随机数字表法随机分为试验组和对照组各40例。对照组予单用腹腔热灌注顺铂化疗，试验组予温阳利水化瘀方联合腹腔热灌注化疗方案。观察并比较两组患者的腹水缓解疗效、中医症状积分、日常生活质量评分（KPS评分）以及不良反应。结果：治疗前，两组各指标无明显差异（P＞0.05）；治疗后，试验组的总有效率优于对照组( P＜0.05)，两组患者中医各症状积分、KPS评分均较治疗前改善（P＜0.05），试验组优于对照组（P＜0.05）；两组患者的肝功能损害、肾功能损害、恶心呕吐和骨髓抑制发生率比较，无明显差异（P＞0.05）。结论：温阳利水化瘀方联合腹腔热灌注化疗治疗恶性腹腔积液可明显缓解患者的腹水情况，改善患者中医症状，从而提高患者的生活质量，减少不良反应的发生，值得进一步研究。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy and safety of Wenyang Lishui Huayu Recipe combined with intraperitoneal hyperthermic perfusion chemotherapy in the treatment of malignant ascites. Methods: We enrolled 80 patients with yang-deficiency malignant ascites admitted to the oncology department and inpatient department of our hospital from July 2016 to July 2018. They were randomly divided into the experimental group and the control group according to the random number table method.The control group was treated with intraperitoneal hyperthermic cisplatin chemotherapy, and the experimental group was treated with Wenyang Lishui Huayu Recipe combined with intraperitoneal hyperthermic perfusion chemotherapy. The ascites relief efficacy, TCM symptom scores, daily life quality score (KPS score) and adverse reactions were observed and compared between the two groups. Results: Before treatment, there was no significant difference between the two groups (P>0.05). After treatment, the total effective rate of the experimental group was better than that of the control group (P<0.05). The symptom scores and KPS scores of the two groups were better than the treatment. The pre-improvement (P<0.05) was better in the experimental group than in the control group (P<0.05). There was no significant difference in the incidence of liver damage, renal dysfunction, nausea and vomiting and myelosuppression between the two groups (P>0.05). Conclusion: Wenyang Lishui Huayu Recipe combined with intraperitoneal hyperthermic perfusion chemotherapy for malignant ascites can significantly relieve the ascites of patients and improve the symptoms of TCM, thus improve the quality of life of patients and reduce the incidence of adverse reactions, which deserves further study. |
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