文章摘要
化纤煎治疗气阴两虚、痰瘀互结型特发性肺纤维化的临床研究
Clinical Study of Huaxian Decoction in Treating Idiopathic Pulmonary Fibrosis with Qi and Yin Deficiency phlegm accumulating with stagnation
投稿时间:2019-07-15  修订日期:2019-07-15
DOI:
中文关键词: 特发性肺纤维化 化纤煎 临床研究
英文关键词: Idiopathic Pulmonary Fibrosis, Huaxian Decoction, Clinical Study
基金项目:基金项目: 上海市卫生和计划生育委员会(2016LP039)
作者单位E-mail
薛鸿浩 上海中医药大学附属龙华医院 13917327582@163.com 
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中文摘要:
      目的 观察化纤煎治疗气阴两虚、痰瘀互结型特发性肺纤维化的临床疗效。方法 采用随机、对照临床研究,纳入符合入组标准IPF患者64例,治疗组33例,对照组31例,两组均采用N-乙酰半胱氨酸基础治疗,治疗组同时予以中药化纤煎干预,观察比较两组治疗前后中医证候积分,肺功能FVC、TLC、DLCO,6min步行距离,Borg呼吸困难评分,SGRQ生活质量评分,血清细胞因子TNF-α、TGF-β指标。结果 治疗结束后,治疗组主要症状喘息、咳嗽、咳痰、胸闷积分及口干口渴、自汗、乏力次要症状积分较治疗前有显著下降(P<0.01),与对照组相比具有显著差异(P<0.01);治疗组肺功能指标FVC、TLC、DLCO较治疗前稍有增加,各指标与治疗前比较无显著差异,两组间比较具有统计学意义(P<0.05);治疗结束后,治疗组与治疗前比较6MWD增加、Borg呼吸困难评分下降,SGRQ生活质量评分有下降(P0.01或P>0.05),与对照组比较具有显著差异(P0.01或P<0.05);治疗组血清TNF-α、TGF-β水平较治疗前下降(P0.05),与对照组比较,统计具有显著差异(P0.05)。结论 中药化纤煎可能通过抑制机体炎症反应,从而对IPF患者发挥治疗作用。
英文摘要:
      Objective To evaluate the clinical efficacy of Huaxian Decoction in the treatment of IPF belong to deficiency of both qi and yin phlegm accumulating with stagnation type. Methods:A randomized, controlled clinical study was performed in 64 patients with IPF who met the inclusion criteria, 33 patients in the treatment group, and 31 patients in the control group. Both groups were treated with N-acetylcysteine,while the treatment group was also treated with Chinese medicine Huaxian Decoction. The TCM syndrome score, lung function FVC, TLC, DLCO, 6 minite walking distance, Borg dyspnea score, SGRQ quality of life score, serum cytokines TNF-α, TGF-β were compared before and after treatment. Result:After treatment, the main symptom wheezing, cough, cough, chest tightness score and the secondary symptom dry mouth thirst, spontaneous sweating, fatigue score of the treatment group were significantly lower than before treatment (P<0.01), which had significant difference compared with the control group. (P<0.01).The lung function index FVC, TLC, DLCO in the treatment group were slightly increased compared with treatment before, But there was no significant difference between treatment before and after. There was significant difference between the two groups after treatment (P<0.05). After treatment, the 6MWD increased, Borg dyspnea score decreased, and SGRQ quality of life score decreased (P<0.01 or P>0.05) in the treatment group, which was significantly different from the control group (P<0.01 or P<0.05). The levels of serum TNF-α and TGF-β of the treatment group were lower than those before treatment (P<0.05). There had significant difference compared with the control group (P<0.05). Conclusion: Huaxian Decoction may exert a therapeutic effect on IPF patients by inhibiting the inflammatory reaction.
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