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复方三棱汤煎剂和复方三棱配方颗粒治疗慢性肾功能衰竭的随机对照观察研究 |
A Randomized Controlled Study of Compound Sanling Decoction and Compound Sanling Formula Granules on Chronic Renal Failure |
投稿时间:2018-09-20 修订日期:2018-09-20 |
DOI: |
中文关键词: 慢性肾功能衰竭 复方三棱汤煎剂 复方三棱配方颗粒 中医药疗法 |
英文关键词: Chronic renal failure compound San Ling Decoction compound prescription of Rhizoma trigarri formula granule Chinese medicine therapy |
基金项目:浙江省中医药科技计划项目:复方三棱配方颗粒和传统煎剂治疗慢性肾衰的临床对比研究,(编号:2017ZK1003) |
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中文摘要: |
目的:观察复方三棱汤和复方三棱颗粒治疗慢性肾功能衰竭的临床疗效。方法:将符合慢性肾功能衰竭诊断标准的62例患者随机分成复方三棱汤组(A组:31例)、复方三棱配方颗粒组(B组:31例),主要干预措施:基础治疗采用优质低蛋白饮食,根据病情采取控制血压和血糖、纠正酸中毒、利尿、纠正贫血及电解质紊乱等对症治疗,复方三棱汤组在基础治疗的基础上加用自拟复方三棱汤煎剂,复方三棱配方颗粒组在基础治疗的基础上加用复方三棱配方颗粒,3个月为一疗程,共2个疗程,最终对治疗效果进行评估。结果:复方三棱汤组总有效率为80.65%,复方三棱配方颗粒组总有效率83.87%。两组相比疗效无明显差异(P>0.05),复方三棱汤组治疗6个月后血清肌酐(Scr)和肌酐清除率(Ccr)与复方三棱配方颗粒组比较无明显差异(P>0.05)。结论:复方三棱汤及复方三棱配方颗粒对改善慢性肾功能衰竭具有较好疗效,两者疗效相仿。 |
英文摘要: |
Objective: To observe the clinical efficacy of Compound Rhizoma trigore Decoction and Compound Rhizoma trigarri granules in treating chronic renal failure. Methods: 62 patients with chronic renal failure were randomly divided into Compound Sanling Decoction group (group A: 31 cases) and Compound Sanling Formula Granule group (group B: 31 cases). The main intervention measures were as follows: basic treatment adopted high-quality low-protein diet, blood pressure and glucose were controlled, acidosis was corrected, diuresis and rectification were carried out according to the condition of the disease. Anemia and electrolyte disorders symptomatic treatment, compound Sanling Decoction group on the basis of basic treatment plus self-made compound Sanling decoction, compound Sanling formula granules group on the basis of basic treatment plus compound Sanling formula granules, three months as a course of treatment, a total of two courses, the final treatment effect was evaluated. Results: the total effective rate of compound trigone Decoction group was 80.65%, and the total effective rate of compound trigone formula granule group was 83.87%. There was no significant difference in curative effect between the two groups (P > 0.05). There was no significant difference in serum creatinine (Scr) and creatinine clearance (Ccr) between the two groups after 6 months of treatment (P > 0.05). Conclusion: Compound Sanling Decoction and Compound Sanling Formula Granule have better curative effect on chronic renal failure, and they have similar curative effect. |
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